Department of Microbiology, All India Institute of Medical Sciences, New Delhi, India.
Indian J Med Res. 2001 Feb;113:60-2.
isepamicin is a new aminoglycoside with a spectrum of activity similar to amikacin with an advantage of possessing a high level of stability against different aminoglycoside modifying enzymes. the in vitro susceptibility of nosocomial isolates obtained from patients admitted to the All India Institute of Medical Sciences, New Delhi during October-December, 1999 was tested against isepamicin and compared with other aminoglycosides.
a total of 251 clinical isolates were studied which included Escherichia coli 87, Klebsiella pneumoniae 54, Pseudonomas aeruginosa 38, Staphylococcus aureus 27 (methicillin resistant S. aureus 15, methicillin sensitive S. aureus 12), Acinetobacter species 26, Enterobacter aerogenes 9, Proteus mirabilis 5, Proteus vulgaris 2, and Citrobacter species 3. The minimum inhibitory concentration (MIC) against isepamicin and other aminoglycosides including amikacin, gentamicin, netilmicin and tobramycin was done using NCCLS guidelines. The cut-off values of isepamicin were used as that of amikacin.
we found that overall 153 nosocomial isolates were sensitive to isepamicin as compared to 95 for amikacin in this hospital. Isepamicin showed a superior in vitro activity compared to the other aminoglycosides tested.
isepamicin can be a good alternative in multidrug resistant nosocomial isolates in hospitals where amikacin resistance is emerging.
异帕米星是一种新型氨基糖苷类抗生素，其抗菌谱与阿米卡星相似，但具有更高的稳定性，不易被各种氨基糖苷类修饰酶所破坏。本研究检测了 1999 年 10 月至 12 月期间在印度全印医学科学院住院患者分离的院内感染病原菌对异帕米星的体外敏感性，并与其他氨基糖苷类抗生素进行了比较。
共检测了 251 株临床分离菌，包括大肠埃希菌 87 株、肺炎克雷伯菌 54 株、铜绿假单胞菌 38 株、金黄色葡萄球菌 27 株（耐甲氧西林金黄色葡萄球菌 15 株、甲氧西林敏感金黄色葡萄球菌 12 株）、不动杆菌属 26 株、产气肠杆菌 9 株、奇异变形杆菌 5 株、普通变形杆菌 2 株和柠檬酸杆菌属 3 株。采用 NCCLS 指南检测异帕米星及其他氨基糖苷类抗生素（阿米卡星、庆大霉素、奈替米星和妥布霉素）的最低抑菌浓度（MIC）。异帕米星的折点值与阿米卡星相同。
与阿米卡星相比，该院 153 株院内感染病原菌对异帕米星敏感，95 株对阿米卡星敏感。异帕米星的体外抗菌活性优于其他检测的氨基糖苷类抗生素。
在出现阿米卡星耐药的医院中，异帕米星可作为多药耐药的院内感染病原菌的替代药物。
