Biswas S K, Kelkar R S
Dept. of Microbiology, Tata Memorial Hospital, Parel, Mumbai 400 012, India.
Indian J Cancer. 2002 Oct-Dec;39(4):135-8.
A comparative study of in vitro activity of amikacin, gentamicin, netilmicin, tobramycin and isepamicin was done. A total of 200 clinical isolates of Gram negative organisms from various clinical sources were tested. E.Coli was the most frequently isolated organism followed by Pseudomonas spp., Klebsiella spp., Proteus spp., Acinetobacter spp. and Enterobacter spp. Of the 5 aminoglycosides tested, isepamicin showed the highest numbers of susceptible isolates followed by amikacin, netilmicin, gentamicin and tobramycin. MIC 90 value of isepamicin was lower as compared to amikacin.
对阿米卡星、庆大霉素、奈替米星、妥布霉素和异帕米星的体外活性进行了比较研究。共检测了来自各种临床来源的200株革兰氏阴性菌临床分离株。大肠埃希菌是最常分离出的菌株，其次是假单胞菌属、克雷伯菌属、变形杆菌属、不动杆菌属和肠杆菌属。在所测试的5种氨基糖苷类药物中，异帕米星显示出的敏感分离株数量最多，其次是阿米卡星、奈替米星、庆大霉素和妥布霉素。与阿米卡星相比，异帕米星的MIC90值更低。
