Li Xiao-ping, Lin Shu, Ye Shuang
Department of Gynecology, The People's Hospital of Fujian Province, Fuzhou 350004.
Zhongguo Zhong Xi Yi Jie He Za Zhi. 2011 Aug;31(8):1070-3.
To study the therapeutic efficacy of Modified Zigui Decoction (MZD) in treatment of polycystic ovary syndrome of Gan-Shen yin deficiency syndrome.
66 polycystic ovary syndrome patients of Gan-Shen yin deficiency syndrome were randomly assigned to the MZD group (Group A) and the Westem medicine group (Group B), 33 patients in each. Patients in Group A orally took MZD, while those in Group B orally took Diane-35. Their menstrual cycle rate, basal body temperature (BBT), the ovarian size, the number of follicles, and changes of endocrine hormones were observed before treatment, the first menstrual cycle, and the sixth menstrual cycle after treatment.
(1) The normal rate of one menstrual cycle after stopping taking medicine was 57.58% in Group A and 63.64% in Group B. There was no statistical difference between the two groups (P>0.05). The normal rate of six menstrual cycles after stopping taking medicine was 45. 45% in Group A and 21.21% in Group B. The former was superior to the latter, showing statistical difference (P<0.05). (2) The biphasic BBT rates of one menstrual cycle after stopping taking medicine were somewhat elevated in the two groups, better than before treatment respectively (P<0.01). But there was no statistical difference between the two groups (P>0.05). The biphasic BBT rate of six menstrual cycles after stopping taking medicine was 45.45% in Group A and 18.18% in Group B. The former was superior to the latter, showing statistical difference (P<0.05). (3) The bilateral ovarian volume of one menstrual cycle after stopping taking medicine was obviously reduced in both groups (P<0.01). The bilateral ovarian volume of six menstrual cycles after stopping taking medicine was still more reduced than before treatment in Group A (P<0.01), while it returned to the size of before treatment in Group B (P>0.05). (4) The number of follicles of one menstrual cycle after stopping taking medicine was obviously reduced in both groups (P<0.01). The number of follicles of six menstrual cycles after stopping taking medicine was still reduced in Group A (P<0.01), while it returned to the number before treatment in Group B (P>0.05). (5) The luteinizing hormone (LH), testosterone (T), LH/FSH ratio of one menstrual cycle after stopping taking medicine were obviously reduced in both groups (P<0.01). They were still more reduced six menstrual cycles after stopping taking medicine than before treatment in Group A (P<0.01), while they returned to the levels of before treatment in Group B (P>0.05).
MZD could effectively treat patients with polycystic ovary syndrome of Gan-Shen yin deficiency syndrome. Besides, its long-term efficacy was more stable and lasting.
探讨加味归芪汤治疗肝肾阴虚型多囊卵巢综合征的疗效。
将66例肝肾阴虚型多囊卵巢综合征患者随机分为加味归芪汤组（A组）和西药组（B组），每组33例。A组口服加味归芪汤，B组口服达英-35。观察两组患者治疗前、停药后第1个月经周期及第6个月经周期的月经周期恢复率、基础体温（BBT）、卵巢大小、卵泡数目及内分泌激素变化。
（1）停药后1个月经周期恢复正常率A组为57.58%，B组为63.64%，两组比较差异无统计学意义（P>0.05）。停药后6个月经周期恢复正常率A组为45.45%，B组为21.21%，A组优于B组，差异有统计学意义（P<0.05）。（2）停药后1个月经周期两组双相BBT率均有所升高，与治疗前比较差异有统计学意义（P<0.01），但两组比较差异无统计学意义（P>0.05）。停药后6个月经周期双相BBT率A组为45.45%，B组为18.18%，A组优于B组，差异有统计学意义（P<0.05）。（3）停药后1个月经周期两组双侧卵巢体积均明显缩小（P<0.01）。停药后6个月经周期A组双侧卵巢体积仍较治疗前缩小（P<0.01），B组恢复至治疗前大小（P>0.05）。（4）停药后1个月经周期两组卵泡数目均明显减少（P<0.01）。停药后6个月经周期A组卵泡数目仍减少（P<0.01），B组恢复至治疗前数目（P>0.05）。（5）停药后1个月经周期两组黄体生成素（LH）、睾酮（T）、LH/FSH比值均明显降低（P<0.01）。停药后6个月经周期A组上述指标较治疗前仍明显降低（P<0.01），B组恢复至治疗前水平（P>0.05）。
加味归芪汤能有效治疗肝肾阴虚型多囊卵巢综合征患者，且远期疗效更稳定持久。
