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Phospholipase A2 enzymes: physical structure, biological function, disease implication, chemical inhibition, and therapeutic intervention.

作者信息

Dennis Edward A, Cao Jian, Hsu Yuan-Hao, Magrioti Victoria, Kokotos George

机构信息

Department of Chemistry and Biochemistry and Pharmacology, School of Medicine, University of California, San Diego, La Jolla, California 92093-0601, USA.

出版信息

Chem Rev. 2011 Oct 12;111(10):6130-85. doi: 10.1021/cr200085w. Epub 2011 Sep 12.

DOI:10.1021/cr200085w
PMID:21910409
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3196595/
Abstract
摘要

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1
Pillars Article: Leukotriene C: A Slow-Reacting Substance from Murine Mastocytoma Cells. 1979. 76: 4275-4279.支柱文章：白三烯C：来自小鼠肥大细胞瘤细胞的一种慢反应物质。1979年。76: 4275 - 4279。
J Immunol. 2018 Mar 1;200(5):1538-1542.
2
Functional Consequences of Mutations and Polymorphisms in the Coding Region of the PAF Acetylhydrolase (PAF-AH) Gene.血小板活化因子乙酰水解酶（PAF-AH）基因编码区突变和多态性的功能后果
Pharmaceuticals (Basel). 2009 Nov 20;2(3):94-117. doi: 10.3390/ph2030094.
3
Combination therapy of an inhibitor of group VIA phospholipase A2 with paclitaxel is highly effective in blocking ovarian cancer development.联合使用组 VIA 磷脂酶 A2 抑制剂与紫杉醇治疗，对于阻断卵巢癌的发展具有高度疗效。
Am J Pathol. 2011 Jul;179(1):452-61. doi: 10.1016/j.ajpath.2011.03.027. Epub 2011 May 17.
4
Blockade of human group X secreted phospholipase A2 (GX-sPLA2)-induced airway inflammation and hyperresponsiveness in a mouse asthma model by a selective GX-sPLA2 inhibitor.选择性人 X 组分泌型磷脂酶 A2（GX-sPLA2）抑制剂对哮喘小鼠气道炎症和高反应性的抑制作用。
J Biol Chem. 2011 Aug 12;286(32):28049-55. doi: 10.1074/jbc.M111.235812. Epub 2011 Jun 7.
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Sequencing of Lp-PLA2-encoding PLA2G7 gene in 2000 Europeans reveals several rare loss-of-function mutations.对 2000 名欧洲人的 Lp-PLA2 编码 PLA2G7 基因进行测序，揭示了几种罕见的失活突变。
Pharmacogenomics J. 2012 Oct;12(5):425-31. doi: 10.1038/tpj.2011.20. Epub 2011 May 24.
6
Lipoprotein-associated phospholipase A(2) interacts with phospholipid vesicles via a surface-disposed hydrophobic α-helix.脂蛋白相关磷脂酶 A(2)通过表面暴露的疏水性α-螺旋与磷脂囊泡相互作用。
Biochemistry. 2011 Jun 14;50(23):5314-21. doi: 10.1021/bi101916w. Epub 2011 May 17.
7
Carriage of the V279F null allele within the gene encoding Lp-PLA₂ is protective from coronary artery disease in South Korean males.载脂蛋白脂蛋白相关磷脂酶 A2 基因编码区 V279F 无义突变等位基因与韩国男性冠心病的保护性相关。
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8
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Clin Exp Allergy. 2011 Jun;41(6):801-10. doi: 10.1111/j.1365-2222.2010.03676.x. Epub 2011 Jan 24.
9
Group XV phospholipase A₂, a lysosomal phospholipase A₂.组 XV 磷脂酶 A₂，溶酶体磷脂酶 A₂。
Prog Lipid Res. 2011 Jan;50(1):1-13. doi: 10.1016/j.plipres.2010.10.006. Epub 2010 Nov 11.
10
1-(5-Carboxyindol-1-yl)propan-2-one inhibitors of human cytosolic phospholipase A2α: effect of substituents in position 3 of the indole scaffold on inhibitory potency, metabolic stability, solubility, and bioavailability.1-(5-羧基吲哚-1-基)丙烷-2-酮类人胞质型磷脂酶 A2α 抑制剂：吲哚骨架 3 位取代基对抑制效力、代谢稳定性、溶解度和生物利用度的影响。
J Med Chem. 2010 Dec 9;53(23):8298-308. doi: 10.1021/jm101094p. Epub 2010 Nov 10.