Jabłonowska Elzbieta, Małolepsza Ewa, Strycharz Marta, Wójcik Kamila
Klinika Chorób Zakaźnych i Hepatologii UM w Łodzi.
Przegl Epidemiol. 2011;65(2):339-43.
Cancers are increasingly recognized as a complication of HIV infection. The traditional AIDS defining cancers (ADCs), including Kaposi sarcoma, cervical cancer, and non-Hodgkin's lymphoma, are common in HIV-positive individuals. However, in the period of antiretroviral therapy the incidence of non-AIDS-defining cancers (NADCs) has increased significantly. The aim of this study was to review the incidence and outcomes of cancers in HIV-infected patients.
Age, sex and CD 4 cells count at the moment of cancer diagnose were assessed.
From 1992 to 2010 year cancers were diagnosed in 30 patients (one patient has two malignancies simultaneously). In study group ADCs were seen in 21 patients (68%) while NADCs were observed in 10 patients (32%). Mean age at the time of diagnose of ADCs and NADCs was 41.9 and 46.6 years, respectively. Mean CD4 cells count at the time of cancer diagnose of ADCs and NADCs was 177.5 and 201,0 cells/microL, respectively. The most common ADCs was non-Hodgkin's lymphoma and NADCs was lung cancer. In presented study only in 10 patients (33%) full remission of malignancy was reported.
ADCs are common group of cancers. Nowadays, in period of antiretroviral therapy NADCs are increasingly problem. The cancer-related mortality in HIV-positive patients is still significant.
癌症越来越被认为是艾滋病毒感染的一种并发症。传统的艾滋病定义性癌症（ADCs），包括卡波西肉瘤、宫颈癌和非霍奇金淋巴瘤，在艾滋病毒阳性个体中很常见。然而，在抗逆转录病毒治疗期间，非艾滋病定义性癌症（NADCs）的发病率显著增加。本研究的目的是回顾艾滋病毒感染患者癌症的发病率和转归。
评估癌症诊断时的年龄、性别和CD4细胞计数。
1992年至2010年期间，30例患者被诊断为癌症（1例患者同时患有两种恶性肿瘤）。研究组中，21例（68%）患者患有ADCs，10例（32%）患者患有NADCs。ADCs和NADCs诊断时的平均年龄分别为41.9岁和46.6岁。ADCs和NADCs癌症诊断时的平均CD4细胞计数分别为177.5和201.0细胞/微升。最常见的ADCs是非霍奇金淋巴瘤，NADCs是肺癌。在本研究中，仅10例（33%）患者报告恶性肿瘤完全缓解。
ADCs是常见的癌症类型。如今，在抗逆转录病毒治疗期间，NADCs问题日益突出。艾滋病毒阳性患者的癌症相关死亡率仍然很高。
