Yama O E, Osinubi A A, Noronha C C, Okanlawon A O
Department of Anatomy, College of Medicine, University of Lagos, Idi-Araba Campus, Lagos, Nigeria.
Nig Q J Hosp Med. 2010 Oct-Dec;20(4):209-13.
A steady weight increase disproportionate to height is by far the most prevalent type of body weight imbalance (overweight and obesity) in apparently healthy individuals of growing age. Many subsisting weight-reduction regimes or formulations are ineffective. Therefore, an effective and affordable weight-reduction product will add to the options available for the management of weight-related conditions.
This study aimed to investigate the effects of graded oral doses of methanolic seed extract of Momordica charantia (MC) on the body weights and cholesterol levels of male rats.
Twenty adult male Sprague-Dawley rats, weighing 176 +/- 70 g, were used for this study. The animals, divided randomly into 4 groups (A-D) received daily graded oral doses of 15, 25 and 50 mg/100 g body weight of methanolic seed extract of MC, respectively, while Group D rats had distilled water for 56 days. The weights of the animals in each group were recorded weekly throughout the duration of the experiment. Serum cholesterol levels were assayed from blood obtained from a left ventricular puncture.
Treatment of rats with MC extract resulted in a dose-dependent, statistically significant (p < 0.05; p < 0.01) reduction in the body weight compared to control. The mean serum cholesterol levels in response to graded doses of MC in the different groups A to C also showed a statistically significant decrease (p < 0.05) from the baseline control value of 4.4 +/- 1.0 mMol/L to 3.4 +/- 0.7, 2.5 +/- 0.4 and 2.0 +/- 1.3 mMol/L, respectively.
Present study demonstrated that MC caused dose-dependent reductions in body weight and serum cholesterol concentration in male Sprague-Dawley rats. MC may, therefore, be useful in controlling body weight increase in individuals of growing age as well as be a potential agent in the management of overweight and obesity.
在明显健康的成长年龄段个体中，体重增长稳定但与身高不成比例是目前最普遍的体重失衡类型（超重和肥胖）。许多现有的减肥方案或配方效果不佳。因此，一种有效且价格合理的减肥产品将增加管理与体重相关病症的可用选择。
本研究旨在调查不同口服剂量的苦瓜甲醇种子提取物（MC）对雄性大鼠体重和胆固醇水平的影响。
本研究使用了20只成年雄性斯普拉格-道利大鼠，体重为176±70克。将动物随机分为4组（A - D），分别每日口服不同剂量的MC甲醇种子提取物，剂量为每100克体重15、25和50毫克，而D组大鼠给予蒸馏水，持续56天。在整个实验期间，每周记录每组动物的体重。通过左心室穿刺采集的血液检测血清胆固醇水平。
与对照组相比，用MC提取物处理大鼠导致体重呈剂量依赖性且具有统计学意义的降低（p < 0.05；p < 0.01）。不同组A至C中，随着MC剂量增加，平均血清胆固醇水平也显示出从基线对照值4.4±1.0毫摩尔/升分别显著降低至3.4±0.7、2.5±0.4和2.0±1.3毫摩尔/升（p < 0.05）。
本研究表明，MC可使雄性斯普拉格-道利大鼠体重和血清胆固醇浓度呈剂量依赖性降低。因此，MC可能有助于控制成长年龄段个体的体重增加，并且可能是管理超重和肥胖的潜在药物。
