Shanghai Key Laboratory of Stomatology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
J Oral Pathol Med. 2012 Feb;41(2):131-5. doi: 10.1111/j.1600-0714.2011.01078.x. Epub 2011 Sep 13.
Oral verrucous hyperplasia (VH) and verrucous carcinoma (VC) are two clinicopathologically distinctive oral verrucous lesions. The objective of this study was to investigate the clinicopathological features of the two verrucous lesions and estimate their relationship from China.
Retrospective review of two series of patients with histologically confirmed VH (n = 121) and VC (n = 56) between 1996 and 2009 in our hospital were conducted.
The average age of VH was 58.5 years (ratio male:female = 1.37) with the tongue being the predominant site. The average age of VC was 64.3 years (ratio male:female = 1.15) with the lower lip being the predominant site. Multivariate analysis revealed that the elderly patient with verrucous lesion (≥60 years) was associated with 3.06-fold (P = 0.007) increased carcinoma risk compared with the non-elderly patient. The lesion located on lower lip was associated with 13.54-fold (P < 0.001) increased carcinoma risk compared with other sites.
Clinicopathological features of VH and VC in China were elucidated. Elderly patient with oral verrucous lesion located on the lower lip correlates with higher risk of carcinoma.
口腔疣状增生（VH）和疣状癌（VC）是两种具有临床病理特征的口腔疣状病变。本研究旨在探讨这两种疣状病变的临床病理特征，并评估它们之间的关系。
回顾性分析 1996 年至 2009 年期间在我院经组织学证实的 VH（n = 121）和 VC（n = 56）患者的临床病理资料。
VH 的平均年龄为 58.5 岁（男：女 = 1.37），以舌部为主要发病部位。VC 的平均年龄为 64.3 岁（男：女 = 1.15），以下唇为主要发病部位。多因素分析显示，老年患者（≥60 岁）与非老年患者相比，患癌风险增加 3.06 倍（P = 0.007）。位于下唇的病变与其他部位相比，患癌风险增加 13.54 倍（P < 0.001）。
阐明了中国 VH 和 VC 的临床病理特征。位于下唇的口腔疣状病变老年患者与更高的癌风险相关。
