Kawakami Eiichi, Yagi Tomoko, Kobayashi Masanori, Hori Tatsuya
Laboratory of Reproduction, Nippon Veterinary and Life Science University, 1–7–1 Kyonancho, Musashino-shi, Tokyo 180–8602, Tokyo, Japan.
J Vet Med Sci. 2012 Feb;74(2):201-4. doi: 10.1292/jvms.11-0272. Epub 2011 Sep 14.
A Beagle dog (3 years old) that ejaculated high percentages (mean ± SE: 29.1 ± 1.2%) of sperm with a knobbed acrosome abnormality and a low number of sperm and that also had a low plasma testosterone (T) level was given 10 subcutaneous injections of 1 µg of gonadotropin-releasing hormone analogue (GnRH-A) at 3-day intervals. The plasma T level and number of sperm increased 12-14 weeks after the first injection. Although the percentages of sperm with knobbed acrosome abnormality did not change after the GnRH-A therapy, the number of sperm and percentage of actively motile sperm increased after the therapy, and a bitch gave birth to 5 healthy puppies after intravaginal artificial insemination with fresh semen collected 14 weeks after the first injection.
