Trookman Nathan S, Rizer Ronald L, Ho Elizabeth T, Ford Rosanne O, Gotz Vincent
Colorado Springs Dermatology Clinic, PC, USA.
Cutis. 2011 Jul;88(1 Suppl):7-12.
The stratum corneum typically is compromised in patients with atopic dermatitis (AD). Beneficial AD treatments should provide moisture to the skin as well as restore impaired barrier function. Traditional treatments involve ointments or creams. A clinical study was conducted to determine if desonide in a hydrogel vehicle (HGV) could improve the moisture content and barrier function of the stratum corneum in adults with mild to moderate AD. Participants applied desonide hydrogel 0.05% twice daily for 4 weeks to areas of both lesional and nonlesional skin. Corneometry and transepidermal water loss (TEWL) were measured at baseline and weeks 1, 2, and 4. Statistically significant improvements in corneometry and TEWL measurements on lesional skin were observed at all study visits compared with baseline (all P < or = .002 and P < or = .04, respectively).
特应性皮炎（AD）患者的角质层通常会受损。有效的AD治疗应能为皮肤提供水分，并恢复受损的屏障功能。传统治疗方法包括使用软膏或乳膏。开展了一项临床研究，以确定水凝胶载体（HGV）中的地奈德是否能改善轻度至中度AD成人患者角质层的水分含量和屏障功能。参与者每天两次在皮损和非皮损皮肤区域涂抹0.05%的地奈德水凝胶，持续4周。在基线以及第1、2和4周测量角质层含水量和经表皮水分流失（TEWL）。与基线相比，在所有研究访视中，皮损皮肤的角质层含水量和TEWL测量值均有统计学意义的改善（分别为所有P≤0.002和P≤0.04）。
