Kircik Leon
J Drugs Dermatol. 2014 Jun;13(6):725-8.
Itch is a common and troubling symptom of atopic dermatitis. It is not mediated by histamine, and standard anti-itch therapies, therefore, have limited benefit for most AD patients. Instead, anti-inflammatory agents are used to reduce inflammation and therefore improve associated itch. Studies confirm that long-term use of corticosteroids can lead to a reduction in pruritus. A pilot study was designed to assess the effects of one week of twice-daily application of desonide hydrogel 0.05% for the treatment of atopic dermatitis. Active treatment was associated with significant improvements in IGA scores at day 3 and day 7 (mean score 0.55, 75.83% improvement from Baseline; P <.0001) and pruritus VAS scores at day 3 and day 7 (mean 6.35-point, 86.61% reduction in VAS scores; P <.0001). Treatment with the convenient, hydrating hydrogel formulation is effective and associated with an improvement in subjects' quality of life.
瘙痒是特应性皮炎常见且令人困扰的症状。它并非由组胺介导，因此标准的止痒疗法对大多数特应性皮炎患者的益处有限。相反，抗炎药物用于减轻炎症，从而改善相关的瘙痒症状。研究证实，长期使用皮质类固醇可导致瘙痒减轻。一项试点研究旨在评估每日两次涂抹0.05%的地奈德水凝胶一周治疗特应性皮炎的效果。积极治疗在第3天和第7天与IGA评分显著改善相关（平均评分0.55，较基线改善75.83%；P<.0001），在第3天和第7天瘙痒视觉模拟评分（VAS）也显著改善（平均降低6.35分，VAS评分降低86.61%；P<.0001）。使用这种方便的保湿水凝胶制剂进行治疗是有效的，且与受试者生活质量的改善相关。
