Clinical Cytology Laboratory, Department of Clinical Analysis and Biomedicine, State University of Maringá, Brazil.
Acta Derm Venereol. 2012 Jan;92(1):78-82. doi: 10.2340/00015555-1194.
The aim of this study was to determine and compare the efficacy of treatment with fluconazole and nystatin in Brazilian women with vaginal Candida. In a population of 932 women, vaginal cultures were performed for yeasts, whether or not the women showed signs and symptoms of vulvovaginal candidiasis. Yeasts were isolated from 12.2% of the women (114/932): 53.2% of the yeasts were Candida albicans, 27.0% C. glabrata, 13.5% C. tropicalis and 6.3% C. parapsilosis. Treatment was carried out with both drugs. The overall mean cure rates with fluconazole (87.0%) and nystatin (74.0%) were similar; among women with non-albicans, the cure rate with fluconazole was 100%, whereas that with nystatin was 44.4%. The cure rate for women with C. albicans was high with both fluconazole and nystatin; however, for those with non-albicans species the cure rate was excellent with fluconazole and very low with nystatin, differing from the majority of in vitro studies.
本研究旨在确定并比较氟康唑和制霉菌素治疗巴西阴道念珠菌病女性患者的疗效。在对 932 名女性进行的阴道培养中，无论女性是否出现外阴阴道假丝酵母菌病的症状和体征，均对酵母菌进行了检测。从 12.2%的女性（114/932）中分离出酵母菌：53.2%为白色念珠菌，27.0%为光滑念珠菌，13.5%为热带假丝酵母菌，6.3%为近平滑假丝酵母菌。使用两种药物进行了治疗。氟康唑（87.0%）和制霉菌素（74.0%）的总体平均治愈率相似；非白念珠菌感染的女性中，氟康唑的治愈率为 100%，而制霉菌素的治愈率为 44.4%。氟康唑和制霉菌素对白念珠菌感染的女性治愈率均较高；然而，对于非白念珠菌感染的女性，氟康唑的治愈率很高，而制霉菌素的治愈率非常低，这与大多数体外研究结果不同。
