Department of Health Sciences, University of Genoa, Via Pastore 1, 16132, Genoa, Italy.
Expert Rev Vaccines. 2011 Sep;10(9):1337-51. doi: 10.1586/erv.11.103.
Invasive infections caused by Neisseria meningitidis are a serious public health problem worldwide and have a heavy economic impact. The incidence of invasive disease due to Neisseria meningitidis is highly variable according to geographical area and serogroup distribution. Since the introduction of vaccination programs with conjugated vaccine C in children and adolescents, most cases of invasive meningococcal disease in developed countries have been caused by meningococcus B. It is important to underline that invasive meningococcal disease will not be controlled until safe and effective vaccines for meningococcal B are available and widely used. The aims of this article are to describe the most recent developments in meningococcal B vaccines and to discuss how these vaccines can contribute to containing meningococcal disease.
脑膜炎奈瑟菌引起的侵袭性感染是全球范围内一个严重的公共卫生问题，对经济造成了沉重的影响。根据地理位置和血清群分布的不同，脑膜炎奈瑟菌引起的侵袭性疾病的发病率差异很大。自从在儿童和青少年中引入结合疫苗 C 接种计划以来，发达国家的大多数侵袭性脑膜炎球菌病都是由脑膜炎球菌 B 引起的。重要的是要强调，在有安全有效的脑膜炎球菌 B 疫苗并广泛使用之前，侵袭性脑膜炎球菌病不会得到控制。本文的目的是描述脑膜炎球菌 B 疫苗的最新进展，并讨论这些疫苗如何有助于控制脑膜炎球菌病。
