Department of Oral Surgery, Heinrich Heine University, Düsseldorf, Germany.
Clin Oral Implants Res. 2012 Mar;23(3):308-15. doi: 10.1111/j.1600-0501.2011.02238.x. Epub 2011 Sep 15.
To assess the influence of two barrier membranes and two bone graft substitutes on staged guided bone regeneration and osseointegration of titanium implants in dogs.
Saddle-type defects were prepared in the lower jaws of 6 fox hounds and randomly filled with a natural bone mineral (NBM) and a biphasic calcium phosphate (SBC) and allocated to either an in situ gelling polyethylene glycol (PEG) or a collagen membrane (CM). At 8 weeks, modSLA titanium implants were inserted and left to heal in a submerged position. At 8+2 weeks, respectively, dissected blocks were processed for histomorphometrical analysis (e.g., mineralized tissue [MT], bone-to-implant contact [BIC]).
The mean MT values (mm2) and BIC values (%) tended to be higher in the PEG groups (MT: NBM [3.4±1.7]; SBC [4.2±2]/BIC: NBM [67.7±16.9]; SBC [66.9±17.8]) when compared with the corresponding CM groups (MT: NBM [2.5±0.8]; SBC [2.3±1.6]/BIC: NBM [54.1±22.6]; SBC [61±8.7]). These differences, however, did not reach statistical significance.
It was concluded that all augmentation procedures investigated supported bone regeneration and staged osseointegration of modSLA titanium implants.
评估两种屏障膜和两种骨替代物对犬下颌骨钛种植体分阶段引导骨再生和骨整合的影响。
在下颌骨的鞍状缺损中分别植入天然骨矿物质（NBM）和双相磷酸钙（SBC），并随机分配到原位凝胶聚乙二醇（PEG）或胶原膜（CM）中。8 周后，将 modSLA 钛种植体插入并在水下位置愈合。8+2 周时，分别对解剖块进行组织形态计量学分析（如矿化组织[MT]、骨与种植体接触[BIC]）。
PEG 组的平均 MT 值（mm2）和 BIC 值（%）（MT：NBM [3.4±1.7]；SBC [4.2±2]/BIC：NBM [67.7±16.9]；SBC [66.9±17.8]）与相应的 CM 组（MT：NBM [2.5±0.8]；SBC [2.3±1.6]/BIC：NBM [54.1±22.6]；SBC [61±8.7]）相比，有更高的趋势。然而，这些差异没有达到统计学意义。
所有研究的增强程序都支持 modSLA 钛种植体的骨再生和分阶段骨整合。
