Vierra Matthew, Mau Lian Ping, Huynh-Ba Guy, Schoolfield John, Cochran David L
Department of Periodontics, University of Texas Health Science Center at San Antonio (UTHSCSA), San Antonio, TX, USA.
Department of Dentistry, Chi Mei Medical Center, Tainan City, Taiwan.
Clin Oral Implants Res. 2016 Jan;27(1):73-82. doi: 10.1111/clr.12517. Epub 2014 Nov 10.
To evaluate guided bone regeneration outcomes in defects protected with an in situ formed polyethylene glycol (PEG) hydrogel membrane as compared to a non-cross-linked collagen membrane (CM).
Four mandibular alveolar ridge defects were created in eight hound dogs. Regenerative procedures were randomly allocated to one of four groups consisting of freeze-dried bone allograft, which is referred to in this study as freeze-dried bone xenograft (FDBX) + PEG, autogenous bone (AB) + PEG, AB + CM, and AB alone. After 8 weeks, titanium dental implants were placed into augmented sites. After 8 weeks of allowed time for osseointegration, the animals were sacrificed to harvest block specimens for bone-to-implant contact (BIC) and ridge width histomorphometric analysis.
Polyethylene glycol membranes had an exposure rate of 50% as compared to 12.5% for sites grafted with CM. Regenerative outcomes with respect to implant placement were least favorable for FDBX + PEG which had implants placed in 37.5% of augmented sites compared to 100% implant placement for all other groups. No statistically significant differences were noted between groups for ridge width measurements in implant and non-implant histologic sections (P > 0.05). Buccal BIC (%) values between treatment groups also failed to reach statistical significant difference (FDBX + PEG [60.2 ± 9.4]; AB + PEG [58.8 ± 8.5]; AB + CM [57.9 ± 12.8]; AB [61.0 ± 10.2]).
When used in conjunction with FDBX, PEG had unpredictable bone formation and in most cases negatively impacted future implant placement.
评估与非交联胶原膜（CM）相比，原位形成的聚乙二醇（PEG）水凝胶膜保护的缺损部位引导骨再生的效果。
在8只猎犬的下颌牙槽嵴制造4处缺损。将再生程序随机分配到四组之一，这四组分别为冻干异体骨移植（本研究中称为冻干异种骨移植，即FDBX）+PEG、自体骨（AB）+PEG、AB+CM以及单纯AB。8周后，将钛牙种植体植入增量部位。在给予8周的骨整合时间后，处死动物以获取块状标本，用于骨与种植体接触（BIC）及牙槽嵴宽度的组织形态计量分析。
PEG膜的暴露率为50%，而CM移植部位的暴露率为12.5%。就种植体植入而言，FDBX+PEG的再生效果最差，其种植体植入了37.5%的增量部位，而其他所有组的种植体植入率均为100%。在种植体和非种植体组织学切片的牙槽嵴宽度测量方面，各组之间未观察到统计学上的显著差异（P>0.05）。各治疗组之间的颊侧BIC（%）值也未达到统计学显著差异（FDBX+PEG[60.2±9.4]；AB+PEG[58.8±8.5]；AB+CM[57.9±12.8]；AB[61.0±10.2]）。
当与FDBX联合使用时，PEG的骨形成情况不可预测，且在大多数情况下对未来种植体植入有负面影响。
