急性淋巴细胞白血病患者口腔黏膜炎初始阶段的促炎细胞因子。
Proinflammatory cytokines during the initial phase of oral mucositis in patients with acute lymphoblastic leukaemia.
机构信息
Research Institute, Faculty of Dentistry, University of Zulia, Maracaibo Oncohematology Service, Children's Specialty Hospital, Maracaibo, Venezuela.
出版信息
Int J Paediatr Dent. 2012 May;22(3):191-6. doi: 10.1111/j.1365-263X.2011.01175.x. Epub 2011 Sep 15.
OBJECTIVE
The aim of the study was to compare the production of proinflammatory cytokines during the initial phase of mucositis in patients with acute lymphoblastic leukaemia.
METHODS
A randomized, controlled clinical trial was carried out. Cytokine levels were determined in blood and saliva using ELISA, three times after the administration of methotrexate and only once in the control group.
RESULTS
Comparison of the results showed significant differences for IL-6 and TNF-α in blood and IL-6 in saliva.
CONCLUSION
It would seem that 96 h is an ideal time for determining the parameters evaluated both in blood and in saliva.
目的
本研究旨在比较急性淋巴细胞白血病患者在黏膜炎初始阶段促炎细胞因子的产生情况。
方法
采用随机、对照的临床试验方法。采用 ELISA 法检测血和唾液中的细胞因子水平，甲氨蝶呤给药后 3 次，对照组仅检测 1 次。
结果
比较结果显示，血液中的 IL-6 和 TNF-α 以及唾液中的 IL-6 差异有统计学意义。
结论
96 小时似乎是评估血液和唾液中评估参数的理想时间。
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