Krzaczek Przemysław M, Mitura-Lesiuk Małgorzata, Zawitkowska Joanna, Petkowicz Beata, Wilczyńska Barbara, Drabko Katarzyna
Department of Oral Medicine, Medical University of Lublin, Poland.
Department of Hematology, Oncology and Pediatric Transplantology, II Chair of Pediatrics, Medical University of Lublin, Poland.
Contemp Oncol (Pozn). 2019;23(2):81-86. doi: 10.5114/wo.2019.85878. Epub 2019 Jun 13.
Acute lymphoblastic leukemia is the most common type of childhood cancer, accounting for about 23% of all cancers diagnosed in this age group. The last stage of radical treatment is remission maintenance, during which hospitalization is not necessary. The lesions occurring in the oral cavity caused by medications and chemotherapy may also be directly related to hematological and systemic disorders. The aim of this study was to examine the levels of selected pro- and anti-inflammatory cytokines in saliva and serum of both patients undergoing remission maintenance and those after the cessation of therapy who reported to the hematology clinic of the Pediatric University Hospital in Lublin. The results were later analyzed in relation to the frequency of oral lesions and subjective intensity of oral complaints. The study revealed significant differences in salivary and serum concentrations of TNF-α and IL-10 between test and control groups. Oral lesions were more frequent in patients receiving therapy compared to the control group. Subjective afflictions described by the Visual Analog Scale (VAS) mean values were highest in the control group.
急性淋巴细胞白血病是儿童期最常见的癌症类型，约占该年龄组所有确诊癌症的23%。根治性治疗的最后阶段是缓解期维持，在此期间无需住院。药物和化疗引起的口腔病变也可能与血液学和全身性疾病直接相关。本研究的目的是检测在卢布林儿科大学医院血液科就诊的缓解期维持患者和治疗结束后的患者唾液和血清中选定的促炎和抗炎细胞因子水平。随后将结果与口腔病变的频率和口腔不适的主观强度进行分析。研究发现，试验组和对照组的唾液和血清中TNF-α和IL-10浓度存在显著差异。与对照组相比，接受治疗的患者口腔病变更为频繁。视觉模拟量表（VAS）平均值所描述的主观痛苦在对照组中最高。
