南非西开普省广泛耐药结核病的历史回顾。

A historical review of XDR tuberculosis in the Western Cape province of South Africa.

机构信息

Lung Infection and Immunity Unit, Division of Pulmonology and UCT Lung Institute, Department of Medicine, University of Cape Town.

出版信息

S Afr Med J. 2011 Sep 5;101(9):636-8.

PMID:21920174

Abstract

There are limited data on the temporal relationship between the regional introduction of multidrug-resistant tuberculosis (MDR-TB) treatment and the subsequent development of extensively drug-resistant TB (XDR-TB). The first XDR-TB case in the Western Cape province of South Africa was recorded in 1992, approximately 5 - 7 years after the regional introduction of MDR-TB-like treatment. Between 1990 and 2002 we identified 48 patients with XDR-TB in the Cape Metropole region of the Western Cape province. Patients were predominantly HIV-uninfected and median survival was 10.8 months. XDR-TB has therefore been present in the Western Cape at least since 1992. These data inform public health policy relevant to the introduction of new anti-TB drug regimens.

摘要

关于耐多药结核病（MDR-TB）治疗在区域内的引入与广泛耐药结核病（XDR-TB）随后发展之间的时间关系，数据有限。南非西开普省的首例 XDR-TB 病例记录于 1992 年，大约是在引入 MDR-TB 样治疗后的 5-7 年。1990 年至 2002 年间，我们在西开普省开普都会地区发现了 48 例 XDR-TB 患者。患者主要为 HIV 未感染者，中位生存期为 10.8 个月。因此，至少自 1992 年以来，西开普省就已经存在 XDR-TB。这些数据为新的抗结核药物方案的引入提供了公共卫生政策方面的信息。