Sidappa K T, Krishnamurthy A
Department of Surgical Oncology, Cancer Institute, Chennai - 600 020, India.
Indian J Cancer. 2011 Jul-Sep;48(3):284-8. doi: 10.4103/0019-509X.84912.
Head and neck sarcomas are relatively rare tumors, accounting for only about 2% of all head and neck malignancies and for 4 to 10% of all soft tissue sarcomas. The rarity and more over the heterogeneity of these tumors make rigorous study of their clinical behavior difficult.
We analyzed our single center experience of adult soft tissue sarcomas of the head and neck.
Our study included 27 patients of adult soft-tissue sarcomas of the head and neck who presented to our center between January 1996 and December 2005.
Patient characteristics, clinical features, treatment modalities, clinical course, and long-term outcomes and its determinants were analyzed.
Surgery in the form of wide excision aimed at achieving negative margins was the main modality of treatment and adjuvant radiation was used in selected patients. The five-year disease-free survival was 64.5% and overall survival (OS) was 68%. Of the multiple potential factors analyzed, univariate analysis showed grade, margin status, and adjuvant radiation to be the important prognostic factors for the survival. The multivariate analysis however only showed margin status and adjuvant radiation to be prognostic.
Surgery with negative margins is a key to long-term survival. Complete resection with adjuvant radiation in selected cases potentially decreases local recurrences and improves OS.
头颈部肉瘤是相对罕见的肿瘤，仅占所有头颈部恶性肿瘤的约2%，占所有软组织肉瘤的4%至10%。这些肿瘤的罕见性以及更重要的是其异质性使得对其临床行为进行严格研究变得困难。
我们分析了我们单中心关于成人头颈部软组织肉瘤的经验。
我们的研究纳入了1996年1月至2005年12月期间在我们中心就诊的27例成人头颈部软组织肉瘤患者。
分析患者特征、临床特征、治疗方式、临床病程、长期结局及其决定因素。
以实现切缘阴性为目标的广泛切除形式的手术是主要治疗方式，部分患者使用了辅助放疗。五年无病生存率为64.5%，总生存率（OS）为68%。在分析的多个潜在因素中，单因素分析显示分级、切缘状态和辅助放疗是生存的重要预后因素。然而，多因素分析仅显示切缘状态和辅助放疗具有预后意义。
切缘阴性的手术是长期生存的关键。在部分病例中进行完整切除并辅以放疗可能会降低局部复发率并提高总生存率。
