Greager J A, Das Gupta T K
Otolaryngol Clin North Am. 1986 Aug;19(3):565-72.
Adult soft tissue sarcomas of the head and neck are so rare that an accurate diagnosis and appropriate therapy are frequently delayed. A retrospective study of such patients seen at the University of Illinois over the last 15 years has helped to better characterize this disease entity. Patients with sarcoma of the neck, the most common anatomic location (37 per cent), had the highest 5-year disease-free survival rate (67 per cent). Fibrosarcoma was the most common histologic type (25 per cent). Aggressive fibromatosis patients experienced the longest mean survival time (93 months). The disease-free 2-year, 5-year, and 10-year survival rates were found to be 68, 54, and 28 per cent, respectively. Wide excision was the treatment of choice, with adjuvant radiotherapy or chemotherapy, or both, used in selected patients. The sarcomas of all long-term survivors were either well-differentiated or 5.0 cm or less in diameter. It is evident that aggressive therapy of adult head and neck sarcomas can provide good long-term results.
成人头颈部软组织肉瘤极为罕见，以至于准确诊断和恰当治疗常常延误。对伊利诺伊大学过去15年收治的此类患者进行的一项回顾性研究，有助于更好地描述这一疾病实体。颈部肉瘤患者是最常见的解剖部位（占37%），其5年无病生存率最高（67%）。纤维肉瘤是最常见的组织学类型（占25%）。侵袭性纤维瘤病患者的平均生存时间最长（93个月）。发现2年、5年和10年无病生存率分别为68%、54%和28%。广泛切除是首选治疗方法，部分患者采用辅助放疗或化疗，或两者兼用。所有长期存活者的肉瘤均为高分化或直径在5.0厘米及以下。显然，积极治疗成人头颈部肉瘤可取得良好的长期效果。
