Faghani M, Ghasemi F M, Nikhbakht M, Salehi M
Department of Anatomical Sciences, Guilan University of Medical Sciences, Rasht, Iran.
Indian J Cancer. 2011 Jul-Sep;48(3):298-302. doi: 10.4103/0019-509X.84925.
Breast cancer is one of the most common cancers in Iranian women. The p53 gene plays a principal role in genomic stability, and its function varies according to polymorphisms. The aim of our study was to determine the relationship between the intron3 16bp duplication polymorphism of the p53 gene and breast cancer in Iranian women.
We performed a case-control study among 145 patients with invasive ductal carcinoma of the breast and 145 controls in Isfahan, Iran. The distribution of the intron3 16bp duplication polymorphism was determined by polymerase chain reaction (PCR). The relationship between clinicopathological data and the PIN3 polymorphism was examined using chi-squared analysis.
A significant difference was observed in the polymorphism variants in breast cancer specimens compared with controls (P < .001). Among the cancer patients, 59.9% were below the age of 50 years; and 67.5% of the patients in this group had the intron3 16bp duplication polymorphism.
PIN3 Ins 16bp duplication polymorphism is a genetically predisposing factor for breast cancer development in Iranian women and may be causal in patients under the age of 50 years.
乳腺癌是伊朗女性中最常见的癌症之一。p53基因在基因组稳定性中起主要作用，其功能因多态性而异。我们研究的目的是确定伊朗女性中p53基因内含子3 16bp重复多态性与乳腺癌之间的关系。
我们在伊朗伊斯法罕对145例浸润性导管癌患者和145例对照进行了病例对照研究。通过聚合酶链反应（PCR）确定内含子3 16bp重复多态性的分布。使用卡方分析检查临床病理数据与PIN3多态性之间的关系。
与对照组相比，乳腺癌标本中的多态性变体存在显著差异（P <.001）。在癌症患者中，59.9%年龄在50岁以下；该组中67.5%的患者具有内含子3 16bp重复多态性。
PIN3 Ins 16bp重复多态性是伊朗女性乳腺癌发生的遗传易患因素，可能是50岁以下患者的病因。
