Lodha R, Joshi A, Paul D, Lodha K M, Nahar N, Shrivastava A, Bhagat V K, Nandeshwar S
Department of Community Medicine, LN Medical College and Research Centre, Bhopal, India.
Indian J Cancer. 2011 Jul-Sep;48(3):303-7. doi: 10.4103/0019-509X.84928.
Epigenetic changes, geography and environmental factors do surpass the genetic factors in the development of breast cancer. This study investigates the association of reproductive factors with the breast cancer in this context.
To detect the association of reproductive risk factors with breast cancer in an urban set up at central India.
Matched paired community-based case-control study.
The study was conducted for a period of a year from October 2008 to August 2009 in Bhopal (MP). Demographic data and reproductive risk factor related information were collected using structured questionnaire. Data analysis was done by Epi-info and SPSS 16.
History of using oral contraceptive pills (OR = 3.02, 95% CI: 1.28-7.11), history of not having breastfeeding (OR = 3.62, 95% CI: 1.29-10.16) and family history of breast cancer (OR = 3.98, 95%CI: 1.06-14.826) were associated significantly with the occurrence of breast cancer in multivariate analysis.
The findings of the present study suggests that positive family history of breast cancer and history of using OCP may be the epigenetic factors promoting the occurrence of breast cancer while breastfeeding reduces the possibility of acquiring breast cancer.
在乳腺癌的发生发展过程中，表观遗传变化、地理位置和环境因素对其的影响超过了遗传因素。本研究在此背景下调查生殖因素与乳腺癌的关联。
在印度中部的一个城市环境中，检测生殖风险因素与乳腺癌的关联。
基于社区的配对病例对照研究。
研究于2008年10月至2009年8月在博帕尔（中央邦）进行，为期一年。使用结构化问卷收集人口统计学数据和与生殖风险因素相关的信息。数据分析采用Epi-info和SPSS 16软件进行。
在多因素分析中，口服避孕药史（OR = 3.02，95%CI：1.28 - 7.11）、未进行母乳喂养史（OR = 3.62，95%CI：1.29 - 10.16）以及乳腺癌家族史（OR = 3.98，95%CI：1.06 - 14.826）与乳腺癌的发生显著相关。
本研究结果表明，乳腺癌家族史阳性和口服避孕药史可能是促进乳腺癌发生的表观遗传因素，而母乳喂养可降低患乳腺癌的可能性。
