与t(14;19)(q32;q13)易位相关的血管内大B细胞淋巴瘤。

Intravascular large B-cell lymphoma associated with t(14;19)(q32;q13) translocation.

作者信息

Kobayashi Taishi, Ohno Hitoshi

机构信息

Department of Hematology, Hyogo Prefectural Amagasaki Hospital, Japan.

出版信息

Intern Med. 2011;50(18):2007-10. doi: 10.2169/internalmedicine.50.5706. Epub 2011 Sep 15.

DOI:10.2169/internalmedicine.50.5706

PMID:21921386

Abstract

We report a 59-year-old man with intravascular large B-cell lymphoma (IVLBCL) associated with hemophagocytic syndrome, disseminated intravascular coagulopathy, and lung involvement. G-banding analysis of the metaphase spreads obtained from the bone marrow showed that the lymphoma cells were near-tetraploid and included two homologues of the 14q+ chromosome. Spectral karyotyping revealed that complex translocations occurred among chromosomes 3, 12, 14, and 19, and additional materials of 14q+ were from chromosome 19 with the breakpoint at 14q32 and 19q13. To the best of our knowledge, this is the first report describing t(14;19)(q32;q13) in IVLBCL.

摘要

我们报告了一名59岁男性，患有血管内大B细胞淋巴瘤（IVLBCL），伴有噬血细胞综合征、弥散性血管内凝血和肺部受累。对从骨髓获得的中期染色体铺片进行G显带分析显示，淋巴瘤细胞接近四倍体，包括14q +染色体的两个同源物。光谱核型分析显示，3号、12号、14号和19号染色体之间发生了复杂易位，14q +的额外物质来自19号染色体，断点位于14q32和19q13。据我们所知，这是首例描述IVLBCL中t(14;19)(q32;q13)的报告。