Department of Pathology, Qianfoshan Hospital Affiliated with Shandong University, , Jinan, Shandong Province, China.
J Clin Pathol. 2014 Mar;67(3):279-81. doi: 10.1136/jclinpath-2013-201980. Epub 2013 Dec 19.
A 61-year-old man with no symptom was found with bilateral adrenal nodules on CT scan during a routine physical check-up. The left nodule was removed by adrenalectomy, and the patient was diagnosed with intravascular large B-cell lymphoma (IVLBCL) on pathological and immunohistochemical examinations. Using a set of dual-colour, break-apart probes and fluorescence in situ hybridisation, it was revealed that the lymphoma cells have tetraploid karyotype, with a breakpoint in BCL6 gene, which was further confirmed as a t(3;14)(q27;q32) translocation. To the best of our knowledge, this is the first report of IVLBCL with such a translocation.
一位 61 岁的男性在常规体检时的 CT 扫描中发现双侧肾上腺结节。左结节通过肾上腺切除术切除，患者在病理和免疫组化检查中被诊断为血管内大 B 细胞淋巴瘤（IVLBCL）。使用一套双色、分离探针和荧光原位杂交技术，显示淋巴瘤细胞具有四倍体核型，BCL6 基因有一个断点，进一步证实为 t（3；14）（q27；q32）易位。据我们所知，这是首例报道具有这种易位的 IVLBCL。
