Department of Nephrology, Osaka City University Graduate School of Medicine, Osaka, Japan.
Nephron Clin Pract. 2011;119(4):c283-8. doi: 10.1159/000328931.
BACKGROUND/AIMS: Little is known about the relationship between fat mass distribution and chronic inflammation in dialysis patients, in whom chronic inflammation is related to morbidity and mortality.
The fat and lean masses (truncal and nontruncal) of 452 hemodialysis patients (age: 64 ± 11 years; hemodialysis duration: 89 ± 77 months; 37% diabetics) were measured by dual X-ray absorptiometry and their association with high-sensitivity C-reactive protein (hsCRP) was examined.
The fat mass of the high hsCRP group (n = 106) was significantly higher than that of the normal hsCRP group (n = 346; p < 0.05); there were no significant differences in lean mass between the two groups. Truncal fat mass of the former group was significantly greater than that of the latter (p < 0.05), but there was no significant difference in nontruncal fat mass between the two groups. In multiple regression analysis, truncal fat mass (β = 0.227, p < 0.01) was significantly and independently associated with serum hsCRP levels after adjustment for age, gender and serum albumin (R(2) = 0.137, p < 0.01), whereas nontruncal fat mass was not.
Fat mass, particularly truncal fat mass, but not lean body mass, was significantly associated with serum hsCRP levels. The results suggest that truncal fat mass exhibits a distinct effect on chronic inflammation in hemodialysis patients.
背景/目的：在透析患者中，脂肪质量分布与慢性炎症之间的关系鲜为人知，而慢性炎症与发病率和死亡率有关。
通过双能 X 射线吸收法测量了 452 名血液透析患者（年龄：64±11 岁；血液透析时间：89±77 个月；37%为糖尿病患者）的脂肪和瘦体重（躯干和非躯干），并检查了它们与高敏 C 反应蛋白（hsCRP）的相关性。
高 hsCRP 组（n=106）的脂肪质量明显高于正常 hsCRP 组（n=346；p<0.05）；两组的瘦体重无明显差异。前一组的躯干脂肪量明显大于后者（p<0.05），但两组的非躯干脂肪量无明显差异。在多元回归分析中，校正年龄、性别和血清白蛋白后，躯干脂肪量（β=0.227，p<0.01）与血清 hsCRP 水平显著独立相关（R²=0.137，p<0.01），而非躯干脂肪量则不然。
脂肪质量，特别是躯干脂肪质量，而不是瘦体重，与血清 hsCRP 水平显著相关。结果表明，躯干脂肪质量对血液透析患者的慢性炎症有明显影响。
