Department of Pediatrics, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, 92093-0687, USA.
Nat Rev Microbiol. 2011 Sep 16;9(10):724-36. doi: 10.1038/nrmicro2648.
Streptococcus pyogenes is also known as group A Streptococcus (GAS) and is an important human pathogen that causes considerable morbidity and mortality worldwide. The GAS serotype M1T1 clone is the most frequently isolated serotype from life-threatening invasive (at a sterile site) infections, such as streptococcal toxic shock-like syndrome and necrotizing fasciitis. Here, we describe the virulence factors and newly discovered molecular events that mediate the in vivo changes from non-invasive GAS serotype M1T1 to the invasive phenotype, and review the invasive-disease trigger for non-M1 GAS. Understanding the molecular basis and mechanism of initiation for streptococcal invasive disease may expedite the discovery of novel therapeutic targets for the treatment and control of severe invasive GAS diseases.
化脓链球菌又称 A 组链球菌（GAS），是一种重要的人类病原体，在全球范围内造成相当大的发病率和死亡率。GAS 血清型 M1T1 克隆是从危及生命的侵袭性（无菌部位）感染中最常分离到的血清型，如链球菌中毒性休克样综合征和坏死性筋膜炎。在这里，我们描述了介导从非侵袭性 GAS 血清型 M1T1 到侵袭表型的体内变化的毒力因子和新发现的分子事件，并回顾了非 M1 GAS 的侵袭性疾病触发因素。了解链球菌侵袭性疾病的分子基础和发病机制可能会加速发现治疗和控制严重侵袭性 GAS 疾病的新治疗靶点。
