Toll样受体4基因多态性与韩国人群正常眼压性青光眼无关。
Toll-like receptor 4 gene polymorphisms do not associate with normal tension glaucoma in a Korean population.
作者信息
Suh Wool, Kim Sungmin, Ki Chang-Seok, Kee Changwon
机构信息
Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
出版信息
Mol Vis. 2011;17:2343-8. Epub 2011 Aug 31.
PURPOSE
To evaluate the association of Toll-like receptor 4 (TLR4) gene polymorphisms with normal tension glaucoma (NTG) in the South Korean population.
METHODS
A total of 147 normal tension glaucoma patients in South Korea were recruited from April, 2007 to August, 2008. Allele, genotype, and haplotype of 8 different types of TLR4 single nucleotide polymorphisms were analyzed: rs10759930, rs1927914, rs1927911, rs12377632, rs2149356, rs11536889, rs7037117, and rs7045953. Three hundred eighty healthy, unrelated South Korean adults were enrolled as controls.
RESULTS
Frequencies of the TLR4 allele did not show any statistically significant difference between normal tension glaucoma patients and the control group (p>0.00625). The same results were observed in genotype frequency analysis. In addition, no statistically significant difference was observed in the frequency of haplotypes in cases of normal tension glaucoma when compared with controls.
CONCLUSIONS
TLR4 single nucleotide polymorphisms are not associated with normal tension glaucoma. Findings from this study suggest that TLR4 polymorphisms may not play an important role in NTG pathogenesis in the South Korean population.
目的
评估韩国人群中Toll样受体4（TLR4）基因多态性与正常眼压性青光眼（NTG）的相关性。
方法
2007年4月至2008年8月期间，共招募了147例韩国正常眼压性青光眼患者。分析了8种不同类型的TLR4单核苷酸多态性的等位基因、基因型和单倍型：rs10759930、rs1927914、rs1927911、rs12377632、rs2149356、rs11536889、rs7037117和rs7045953。招募380名健康、无亲缘关系的韩国成年人作为对照。
结果
正常眼压性青光眼患者与对照组之间TLR4等位基因频率无统计学显著差异（p>0.00625）。基因型频率分析结果相同。此外，与对照组相比，正常眼压性青光眼患者单倍型频率无统计学显著差异。
结论
TLR4单核苷酸多态性与正常眼压性青光眼无关。本研究结果表明，TLR4多态性可能在韩国人群NTG发病机制中不起重要作用。
Zotero 插件