Power Kristin M, Sanchez-Galan Javier E, Luskey Gary W, Koski Kristine G, Burns David H
Department of Chemistry, McGill University, Montreal, QC, Canada H3A 2K6.
J Pregnancy. 2011;2011:980985. doi: 10.1155/2011/980985. Epub 2011 Sep 13.
This pilot study investigated the possibility that metabolomic differences exist in second trimester of women delivering at term (≥37 weeks, n = 216) and preterm (≤35 weeks, n = 11). For this retrospective study, biobanked AF samples underwent near-infrared (NIR) spectral analysis using wavelengths from 700 to 1050 nm. Spectral data was compressed then optimized by multilinear regression to create a calibration model. The resultant model was able to classify term and preterm births based on differing AF metabolomic profiles with a sensitivity and specificity of 100%. When groups were classified using a prematurity index (PI), there was a statistical difference (P < 0.001) between the predicted preterm group (PI 0.77 ± 0.08) and the term group (PI 1.00 ± 0.02). In conclusion, the 2nd trimester AF samples showed distinct differences in metabolomic profiles between patients delivering preterm as compared to those at term in functional groups related to proteins, carbohydrates, fats, polyols, and water.
这项初步研究调查了足月分娩（≥37周，n = 216）和早产（≤35周，n = 11）女性妊娠中期代谢组学差异存在的可能性。对于这项回顾性研究，对生物样本库中的羊水样本进行了近红外（NIR）光谱分析，使用700至1050nm的波长。光谱数据经过压缩，然后通过多元线性回归进行优化，以创建校准模型。所得模型能够根据不同的羊水代谢组学特征对足月和早产进行分类，灵敏度和特异性均为100%。当使用早产指数（PI）对组进行分类时，预测早产组（PI 0.77±0.08）和足月组（PI 1.00±0.02）之间存在统计学差异（P<0.001）。总之，与足月分娩患者相比，妊娠中期羊水样本在蛋白质、碳水化合物、脂肪、多元醇和水相关功能组中，早产患者的代谢组学特征存在明显差异。
