Jazwinski S M
Department of Biochemistry and Molecular Biology, Louisiana State University Medical Center, New Orleans 70112.
Mol Microbiol. 1990 Mar;4(3):337-43. doi: 10.1111/j.1365-2958.1990.tb00601.x.
The budding yeast Saccharomyces cerevisiae has a limited life span, defined by the number of times an individual cell divides. Longevity in this organism involves a genetic component. Several morphological and physiological changes are associated with yeast aging and senescence. One of these, an increase in generation time with age, provides a 'biomarker' for the aging process. This increase in generation time has revealed the operation of a 'senescence factor(s)', which is likely to be a product of age-specific gene expression. The Cell Spiral Model indicates coordination of successive cell cycles to be inherent in the determination of life span. It is proposed that life expectancy depends on the function of a stochastic trigger during aging that sets in motion a programme leading to cell senescence and death.
出芽酵母酿酒酵母的寿命有限，由单个细胞分裂的次数决定。这种生物体的长寿涉及遗传成分。酵母衰老和老化与几种形态和生理变化相关。其中之一是随着年龄增长世代时间增加，这为衰老过程提供了一个“生物标志物”。世代时间的这种增加揭示了一种“衰老因子”的作用，它可能是特定年龄基因表达的产物。细胞螺旋模型表明连续细胞周期的协调是寿命决定中固有的。有人提出，预期寿命取决于衰老过程中一个随机触发因素的功能，该因素启动一个导致细胞衰老和死亡的程序。
