Chang Qiang, Pan Shijie, Lu Feng
Department of Plastic Surgery, Nanfang Hospital of Southern Medical University, Guangzhou Guangdong 510515, PR China.
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2011 Aug;25(8):1008-13.
To review the research status of the neovascularization of adipose tissue engineering in the past decade so as to provide theoretical references for the development of the rapid revascularization of tissue engineered adipose.
The literature about the revascularization of adipose tissue engineering was extensively reviewed and analyzed, centering on 5 elements: specificity of histological structures and blood supply, revascularization mechanism, coculture of different seed cells, modification of scaffold, and microenvironment.
Adipose tissue engineering offers a new solution for soft tissue defects. However, there is still the unfulfilled need in the size of engineered adipose tissue (less than 1 mL), which was determined by the degree of neovascularization in engineered tissue. Overall, rapid neovascularization in engineering tissue is a key link of experimental study changing into clinical application.
Providing a sufficient supply with nutrients and oxygen by means of a sufficient and rapid neovascularization will be at the heart of any attempts to obtain bigger tissue engineered adipose to meet the demand of repairing large soft tissue defect.
回顾近十年来脂肪组织工程血管化的研究现状，为组织工程化脂肪快速血管化的发展提供理论参考。
围绕组织结构与血供特异性、血管化机制、不同种子细胞共培养、支架修饰及微环境5个要素，广泛查阅并分析脂肪组织工程血管化相关文献。
脂肪组织工程为软组织缺损提供了新的解决方案。然而，工程化脂肪组织的大小（小于1 mL）仍无法满足需求，这是由工程组织内血管化程度决定的。总体而言，工程组织内的快速血管化是实验研究转化为临床应用的关键环节。
通过充分且快速的血管化提供充足的营养和氧气供应，将是获取更大的组织工程化脂肪以满足修复大面积软组织缺损需求的任何尝试的核心。
