Clark Matthew D, Guryev Victor, Bruijn Ewart de, Nijman Isaac J, Tada Masazumi, Wilson Catherine, Deloukas Panos, Postlethwait John H, Cuppen Edwin, Stemple Derek L
Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK.
Methods Cell Biol. 2011;104:219-35. doi: 10.1016/B978-0-12-374814-0.00013-6.
Despite considerable genetic and genomic resources the positional cloning of forward mutations remains a slow and manually intensive task, typically using gel based genotyping and sequential rounds of mapping. We have used the latest genetic resources and genotyping technologies to develop two commercially available SNP panels of thousands of markers that can be used to speed up positional cloning.
尽管有大量的遗传和基因组资源，但正向突变的定位克隆仍然是一项缓慢且人工密集的任务，通常使用基于凝胶的基因分型和连续多轮的定位。我们利用最新的遗传资源和基因分型技术开发了两个包含数千个标记的商业可用SNP面板，可用于加速定位克隆。
