Hurault-Delarue C, Lacroix I, Vidal S, Montastruc J-L, Damase-Michel C
EA3696, unité de pharmacoépidémiologie, service de pharmacologie clinique, faculté de médecine, université de Toulouse, CHU de Toulouse 37, allées Jules-Guesde, Toulouse, France.
Gynecol Obstet Fertil. 2011 Oct;39(10):554-8. doi: 10.1016/j.gyobfe.2011.07.044. Epub 2011 Sep 15.
To analyze the evolution of drug prescriptions during pregnancy from 2004 to 2008 in Haute-Garonne (France) and the impact of recommendations concerning drugs in pregnancy sent by French health authorities (AFSSAPS) and French college of gynaecologists and obstetricians to health professionals during the period.
This descriptive study of reimbursed drug prescriptions during pregnancy concerns women included in the EFEMERIS database who have given birth from July 1st, 2004 to June 30th, 2008. The health insurance service records of Haute-Garonne were used.
Taking into account 2 subsequent delistings of drugs for reimbursement during the period, we observed a significant increase of reimbursed drug prescriptions dispensed to pregnant women (8.7 different substances for women who have given birth in 2004 and 9.4 in 2008). Vitamins, immunserums, immunoglobulins and homeopathy prescriptions have especially increased. Paracetamol, iron, folic acid and phloroglucinol were the most prescribed drugs during all the periods.
Since 2004, EFEMERIS represents a monitoring centre for the prescription of reimbursed drugs to pregnant women. This analysis allowed to exhibit trends in prescription patterns. Most of the alerts or recommendations had a positive but limited impact.
分析2004年至2008年法国上加龙省孕期药物处方的演变情况，以及在此期间法国卫生当局（AFSSAPS）和法国妇产科医生学会向卫生专业人员发送的孕期用药建议的影响。
这项关于孕期报销药物处方的描述性研究涉及EFEMERIS数据库中2004年7月1日至2008年6月30日期间分娩的妇女。使用了上加龙省的医疗保险服务记录。
考虑到该期间两种药物随后被取消报销资格，我们观察到向孕妇发放的报销药物处方显著增加（2004年分娩的妇女有8.7种不同药物，2008年为9.4种）。维生素、免疫血清、免疫球蛋白和顺势疗法处方尤其增加。对乙酰氨基酚、铁、叶酸和间苯三酚是所有时期处方最多的药物。
自2004年以来，EFEMERIS一直是孕妇报销药物处方的监测中心。该分析揭示了处方模式的趋势。大多数警报或建议产生了积极但有限的影响。
