Department of Biochemistry and Cell Biology, Institute for Cell and Developmental Biology, Stony Brook University, Stony Brook, NY 11794-5215, USA.
Curr Opin Struct Biol. 2011 Oct;21(5):583-9. doi: 10.1016/j.sbi.2011.08.008. Epub 2011 Sep 15.
The Notch family of receptors plays essential roles in many phases of development, and dysregulation of Notch activity is increasingly recognized as a player in many diseases. O-Glycosylation of the Notch extracellular domain is essential for Notch activity, and tissue-specific alterations in the glycan structures are known to regulate activity. Here we review recent advances in identification and characterization of the enzymes responsible for glycosylating Notch and molecular mechanisms for how these O-glycans affect Notch activity.
Notch 受体家族在许多发育阶段都发挥着重要作用, Notch 活性的失调越来越被认为是许多疾病的一个参与者。 Notch 细胞外结构域的 O-糖基化对于 Notch 活性是必需的,并且已知组织特异性的聚糖结构改变可调节活性。在这里,我们综述了鉴定和表征负责糖基化 Notch 的酶的最新进展,以及这些 O-聚糖如何影响 Notch 活性的分子机制。