Department of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, NY 11794-5215, USA.
Semin Cell Dev Biol. 2010 Aug;21(6):638-45. doi: 10.1016/j.semcdb.2010.03.003. Epub 2010 Mar 10.
The Notch pathway is one of the major signaling pathways required for proper development in metazoans. Notch activity is regulated at numerous levels, and increasing evidence reveals the importance of "protein glycosylation" (modification of Notch receptors with sugars) for its regulation. In this review we summarize the significance of the Notch pathway in development and the players responsible for its glycosylation, and then discuss the molecular mechanisms by which protein glycosylation may regulate Notch function.
Notch 通路是后生动物正常发育所必需的主要信号通路之一。 Notch 活性在多个水平上受到调控,越来越多的证据表明“蛋白糖基化”(糖基化 Notch 受体)对于其调控的重要性。在这篇综述中,我们总结了 Notch 通路在发育中的重要性及其糖基化的作用因子,然后讨论了蛋白糖基化可能调节 Notch 功能的分子机制。