Aberdeen Fungal Group, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen AB25 2ZD, UK.
Cytokine. 2012 Apr;58(1):89-99. doi: 10.1016/j.cyto.2011.08.031. Epub 2011 Sep 15.
Fungi are the cause of opportunistic infections, predominantly in immunocompromised individuals although, primary fungal infections can occur in apparently healthy individuals. Successful host defence requires an effective innate and adaptive immune response. Central to host immune responses are the induction of cytokines; the signals which help to activate the innate immune system and which play a central role in directing the development of pathogen-specific immunity. C-type lectins play a central role in the recognition and shaping of immune responses to fungal pathogens, in part, through the induction and modulation of cytokine responses. Understanding which cytokines induce protective responses to these pathogens and how C-type lectins and other receptors direct cytokine production may allow development of novel antifungal therapies. Here we review the C-type lectins, their influence on cytokine production and subsequent immune responses in antifungal immunity.
真菌是机会性感染的原因，主要发生在免疫功能低下的个体中，尽管原发性真菌感染也可能发生在看似健康的个体中。成功的宿主防御需要有效的先天和适应性免疫反应。宿主免疫反应的核心是细胞因子的诱导；这些信号有助于激活先天免疫系统，并在指导针对病原体的特异性免疫的发展中发挥核心作用。C 型凝集素在识别和塑造对真菌病原体的免疫反应中发挥核心作用，部分原因是通过诱导和调节细胞因子反应。了解哪些细胞因子诱导对这些病原体的保护性反应，以及 C 型凝集素和其他受体如何指导细胞因子的产生，可能有助于开发新的抗真菌疗法。在这里，我们回顾了 C 型凝集素及其对细胞因子产生的影响，以及在抗真菌免疫中的后续免疫反应。
