Rappleye Chad A, Goldman William E
Departments of Microbiology and Medicine, Ohio State University, 484 West 12th Avenue, Columbus, OH 43210, USA.
Trends Immunol. 2008 Jan;29(1):18-24. doi: 10.1016/j.it.2007.10.001. Epub 2007 Nov 28.
Medically important fungi range from commensal organisms that cause opportunistic infections to primary fungal pathogens that can cause disease in immunocompetent hosts. Host phagocyte-expressed pattern-recognition receptors represent one obstacle to infection, and the extent to which fungal cells can evade detection by host receptors helps shape their pathogenic potential. This review highlights recently defined mechanisms employed by successful fungal pathogens to conceal their immunostimulatory molecular signatures from leukocyte receptors or to disrupt host response signals. Continued improvements in our understanding of these fungal stealth mechanisms should provide new options for future therapeutics to expose these fungal pathogens and limit their virulence capacity.
具有医学重要性的真菌范围广泛，从引起机会性感染的共生生物到可在免疫功能正常的宿主中致病的原发性真菌病原体。宿主吞噬细胞表达的模式识别受体是感染的一个障碍，真菌细胞能够逃避宿主受体检测的程度有助于塑造它们的致病潜力。本综述重点介绍了成功的真菌病原体最近确定的机制，这些机制用于向白细胞受体隐藏其免疫刺激分子特征或破坏宿主反应信号。我们对这些真菌隐身机制的理解不断改进，应该会为未来的治疗提供新的选择，以暴露这些真菌病原体并限制它们的致病能力。
