Department of Otolaryngology-Head and Neck Surgery, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Oral Oncol. 2012 Jan;48(1):90-4. doi: 10.1016/j.oraloncology.2011.08.020. Epub 2011 Sep 15.
The purpose of this study was to examine treatment outcomes and define factors that influence survival in patients with pN2 oropharyngeal carcinoma. Fifty-five patients underwent primary surgery with postoperative radiotherapy between 1994 and 2009. Primary tumor sites were 36 tonsil, 13 base of tongue, 3 soft palate, and three posterior pharyngeal wall. There were 15, 26, 5, and 9 patients with stage T1 to T4 cancers, respectively. The N stage were 5 N2a, 37 N2b, and 13 N2c. The 5-year disease-specific survival rates were 66%. A significant positive correlation was found between high risk HPV status and extracapsular spread and disease-specific survival rates (HPV (+); 93% vs. HPV (-); 56%, p=0.031 and extracapsular spread (-); 93% vs. extracapsular spread (+); 50%, p=0.008, respectively). Primary surgery with postoperative radiotherapy can be achieved with favorable oncologic outcomes for pN2 oropharyngeal carcinoma. Factors that affected prognosis were HPV status and extracapsular spread.
本研究旨在探讨 pN2 口咽癌患者的治疗结果，并确定影响生存的因素。1994 年至 2009 年间，55 例患者接受了根治性手术联合术后放疗。原发肿瘤部位分别为 36 例扁桃体、13 例舌根、3 例软腭和 3 例咽后壁。分别有 15、26、5 和 9 例患者的 T1 至 T4 期癌症。N 期分别为 5 例 N2a、37 例 N2b 和 13 例 N2c。5 年疾病特异性生存率为 66%。高危 HPV 状态与包膜外扩散和疾病特异性生存率之间存在显著正相关（HPV（+）；93%比 HPV（-）；56%，p=0.031 和包膜外扩散（-）；93%比包膜外扩散（+）；50%，p=0.008）。pN2 口咽癌根治性手术联合术后放疗可获得良好的肿瘤学结果。影响预后的因素是 HPV 状态和包膜外扩散。
