Department of Otolaryngology-Head and Neck Surgery, College of Medicine, The Catholic University of Korea, Seoul, Korea.
PLoS One. 2013 Nov 11;8(11):e78718. doi: 10.1371/journal.pone.0078718. eCollection 2013.
High-risk human papillomavirus (HPV) is an oncogenic virus that causes oropharyngeal cancers, and it has a favorable outcome after the treatment. Unlike in oropharyngeal cancer, the prevalence and role of high-risk HPV in the etiology of hypopharyngeal squamous cell carcinoma (HPSCC) is uncertain.
The aim of the present study was to evaluate the effect and prognostic significance of high-risk HPV in patients with HPSCC.
The study included 64 subjects with HPSCC who underwent radical surgery with or without radiation-based adjuvant therapy. Primary tumor sites were the pyriform sinus in 42 patients, posterior pharyngeal wall in 19 patients, and postcricoid area in 3 patients. High-risk HPV in situ hybridization was performed to detect HPV infection.
The positive rate of high-risk HPV in situ hybridization was 10.9% (7/64). There was a significant difference in the fraction of positive high-risk HPV among pyriform sinus cancer (16.7%), posterior pharyngeal wall cancer (0%), and postcricoid area cancer (0%) (p = 0.042). The laryngoscopic examination revealed a granulomatous and exophytic appearance in 85.7% (6/7) of patients with high-risk HPV-positive pyriform sinus cancer, but in only 31.4% (11/35) of patients with high-risk HPV-negative pyriform sinus cancer (p = 0.012). Significant correlations were found between positive high-risk HPV and younger age (p = 0.050) and non-smoking status (p = 0.017). HPV-positive patients had a significantly better disease-free survival (p = 0.026) and disease-specific survival (p = 0.047) than HPV-negative patients.
High-risk HPV infection is significantly related to pyriform sinus cancer in patients with HPSCC.
高危型人乳头瘤病毒（HPV）是一种致癌病毒，可导致口咽癌，且其治疗效果良好。与口咽癌不同，高危型 HPV 在下咽鳞状细胞癌（HPSCC）病因学中的流行率和作用尚不确定。
本研究旨在评估高危型 HPV 在下咽鳞状细胞癌患者中的作用和预后意义。
本研究纳入了 64 例接受根治性手术加或不加放疗辅助治疗的 HPSCC 患者。原发肿瘤部位为 42 例梨状窝癌、19 例咽后壁癌和 3 例环后区癌。采用高危型 HPV 原位杂交检测 HPV 感染。
高危型 HPV 原位杂交阳性率为 10.9%（7/64）。梨状窝癌（16.7%）、咽后壁癌（0%）和环后区癌（0%）中高危型 HPV 阳性率有显著差异（p=0.042）。7 例高危型 HPV 阳性的梨状窝癌患者中有 85.7%（6/7）表现为肉芽样和外生性外观，而高危型 HPV 阴性的梨状窝癌患者中仅为 31.4%（11/35）（p=0.012）。高危型 HPV 阳性与年龄较小（p=0.050）和不吸烟（p=0.017）显著相关。HPV 阳性患者的无病生存率（p=0.026）和疾病特异性生存率（p=0.047）显著优于 HPV 阴性患者。
高危型 HPV 感染与 HPSCC 患者的梨状窝癌显著相关。
