膜变形AAA型ATP酶Vps4的结构与功能
Structure and function of the membrane deformation AAA ATPase Vps4.
作者信息
Hill Christopher P, Babst Markus
机构信息
Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT 84112-5650, USA.
出版信息
Biochim Biophys Acta. 2012 Jan;1823(1):172-81. doi: 10.1016/j.bbamcr.2011.08.017. Epub 2011 Sep 8.
Abstract
The ATPase Vps4 belongs to the type-I AAA family of proteins. Vps4 functions together with a group of proteins referred to as ESCRTs in membrane deformation and fission events. These cellular functions include vesicle formation at the endosome, cytokinesis and viral budding. The highly dynamic quaternary structure of Vps4 and its interactions with a network of regulators and co-factors has made the analysis of this ATPase challenging. Nevertheless, recent advances in the understanding of the cell biology of Vps4 together with structural information and in vitro studies are guiding mechanistic models of this ATPase.
摘要
ATP酶Vps4属于I型AAA蛋白家族。Vps4与一组被称为内体分选转运复合体（ESCRT）的蛋白质共同作用于膜变形和裂变事件。这些细胞功能包括在内体形成囊泡、细胞分裂和病毒出芽。Vps4高度动态的四级结构及其与调控因子和辅助因子网络的相互作用使得对这种ATP酶的分析具有挑战性。尽管如此，最近在Vps4细胞生物学理解方面的进展以及结构信息和体外研究正在为这种ATP酶的作用机制模型提供指导。
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