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外泌体分子货物在囊泡生成和疾病诊断中的作用。

The role of exosomal molecular cargo in exosome biogenesis and disease diagnosis.

机构信息

Laboratory Medicine, People's Hospital of Ganzhou Economic Development Zone, Ganzhou, China.

Department of Rehabilitation Medicine, The First Affiliated Hospital of Gannan Medical University, GanZhou, China.

出版信息

Front Immunol. 2024 Jun 25;15:1417758. doi: 10.3389/fimmu.2024.1417758. eCollection 2024.

Abstract

Exosomes represent a type of extracellular vesicles derived from the endosomal pathway that transport diverse molecular cargoes such as proteins, lipids, and nucleic acids. These cargoes have emerged as crucial elements impacting disease diagnosis, treatment, and prognosis, and are integral to the process of exosome formation. This review delves into the essential molecular cargoes implicated in the phases of exosome production and release. Emphasis is placed on their significance as cancer biomarkers and potential therapeutic targets, accompanied by an exploration of the obstacles and feasible applications linked to these developments.

摘要

外泌体是一种源自内体途径的细胞外囊泡,可运输多种分子货物,如蛋白质、脂质和核酸。这些货物已成为影响疾病诊断、治疗和预后的关键因素,也是外泌体形成过程中的重要组成部分。本综述深入探讨了参与外泌体产生和释放阶段的重要分子货物。重点介绍了它们作为癌症生物标志物和潜在治疗靶点的意义,并探讨了与这些进展相关的障碍和可行的应用。

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