Center for Immunobiology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Semin Immunol. 2012 Apr;24(2):131-5. doi: 10.1016/j.smim.2011.08.020. Epub 2011 Sep 16.
Lung transplantation is considered a definitive treatment for many lung diseases. However, rejection and other pathologic entities are major causes of morbidity and mortality for lung transplant recipients. Primary graft dysfunction (PGD) and obliterative bronchiolitis (OB) are the leading causes of early and late mortality, respectively. While the immune basis of PGD has not been clearly defined, evidence is emerging about roles for autoantibodies in this process. Similarly, the pathogenesis of OB has been linked recently to autoimmunity. This review will highlight the current understanding of autoantibodies in PGD and OB post lung transplantation.
肺移植被认为是许多肺部疾病的一种有效治疗手段。然而,排斥反应和其他病理实体是肺移植受者发病率和死亡率的主要原因。原发性移植物功能障碍(PGD)和闭塞性细支气管炎(OB)分别是早期和晚期死亡的主要原因。虽然 PGD 的免疫基础尚未明确界定,但有证据表明自身抗体在此过程中起作用。同样,OB 的发病机制最近也与自身免疫有关。这篇综述将重点介绍肺移植后 PGD 和 OB 中自身抗体的最新认识。