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The effect of amylin and calcitonin gene-related peptide on insulin-stimulated glucose transport in the diaphragm.

作者信息

Hothersall J S, Muirhead R P, Wimalawansa S

机构信息

Department of Biochemistry, University College, London, UK.

出版信息

Biochem Biophys Res Commun. 1990 Jun 15;169(2):451-4. doi: 10.1016/0006-291x(90)90352-n.

DOI:10.1016/0006-291x(90)90352-n
PMID:2192706
Abstract

The two peptides calcitonin gene related peptide (CGRP) and amylin at 1 uM levels in an isolated rat diaphragm preparation inhibited insulin stimulated 2-deoxy[3H]glucose transport by 30 and 60 percent, respectively; this was the case at maximal (1 uM) and sub-maximal (0.5 mU) insulin concentrations. No effect was measured on the basal level of 2-deoxy[3H]glucose transport.

摘要

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The effect of amylin and calcitonin gene-related peptide on insulin-stimulated glucose transport in the diaphragm.
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2
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