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8-37h-CGRP antagonizes actions of amylin on carbohydrate metabolism in vitro and in vivo.

作者信息

Wang M W, Young A A, Rink T J, Cooper G J

机构信息

Physiology Department, Amylin Corporation, San Diego, California 92121.

出版信息

FEBS Lett. 1991 Oct 21;291(2):195-8. doi: 10.1016/0014-5793(91)81282-d.

DOI:10.1016/0014-5793(91)81282-d
PMID:1936264
Abstract

8-37hCGRP is a potent antagonist at calcitonin gene-related peptide (CGRP) liver membrane receptors; it also blocks vasodilator actions of CGRP and the related peptide, amylin, in intact rats. We now report that 8-37hCGRP antagonizes amylin inhibition of insulin-stimulated labelled glucose uptake into isolated rat soleus muscle, and inhibits amylin-evoked elevation of plasma lactate and glucose in fasted anaesthetized rats. The different relative potencies of the 3 ligands (amylin, CGRP, 8-37hCGRP) on the liver receptor and on the soleus muscle point to distinct CGRP receptors in liver membranes and amylin receptors on muscle cells.

摘要

相似文献

1
8-37h-CGRP antagonizes actions of amylin on carbohydrate metabolism in vitro and in vivo.
FEBS Lett. 1991 Oct 21;291(2):195-8. doi: 10.1016/0014-5793(91)81282-d.
2
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