Department of Radiology, Dokkyo Medical University, 880 Kita-Kobayashi, Mibu, Tochigi 321-0293, Japan.
Jpn J Radiol. 2011 Oct;29(8):587-9. doi: 10.1007/s11604-011-0590-x. Epub 2011 Sep 17.
A 79-year-old woman with advanced lung cancer presented with worsened radiation fibrosis after administration of erlotinib. After radiation therapy 7 months previously, she had radiation fibrosis that had been stable for months. On the 19th day after administration of erlotinib, low-grade fever and mild dyspnea developed accompanied by new pulmonary opacity in the area of the radiation fibrosis, which improved without therapy. We surmise that this is a manifestation of the radiation recall phenomenon, and discontinuation of the drug should be considered with discretion.
一位 79 岁的女性肺癌患者在服用厄洛替尼后出现进行性放射性纤维化恶化。在 7 个月前接受放射治疗后，她的放射性纤维化已经稳定了数月。厄洛替尼给药后第 19 天，出现低热和轻度呼吸困难，同时伴有放射性纤维化区域的新的肺部不透明影，未经治疗即改善。我们推测这是放射性回忆现象的表现，应慎重考虑停药。
