Schweitzer V G, Juillard G J, Bajada C L, Parker R G
Department of Radiation Oncology, UCLA Medical Center 90024, USA.
Cancer. 1995 Sep 15;76(6):1069-72. doi: 10.1002/1097-0142(19950915)76:6<1069::aid-cncr2820760623>3.0.co;2-7.
Radiation recall refers to a tissue reaction produced by a chemotherapeutic agent in a previously irradiated field that would not occur in a nonirradiated field. A number of agents have been reported to cause radiation recall. Recently, there have been case reports of recall dermatitis from paclitaxel treatment.
A patient with metastatic lung cancer received palliative radiation to her mediastinum and ribs. Because of disease progression, she subsequently received paclitaxel.
After paclitaxel administration, the patient became acutely dyspneic. A subsequent chest X-ray revealed a parenchymal opacity in a region that corresponded with the patient's radiation portal. She also developed a severe skin reaction in the previously treated electron field.
This is one of few reported cases of recall dermatitis from paclitaxel and is also suggestive of recall pneumonitis, a phenomenon previously unreported to the authors' knowledge. Given paclitaxel's ability to function as a radiosensitizer, this response is not unexpected. As the frequency of paclitaxel administration increases, its potential as a radiation sensitizer and radiation recall should be considered.
放射回忆是指化疗药物在先前接受过照射的部位引发的组织反应，而在未接受照射的部位则不会出现这种反应。已有多种药物被报道可引起放射回忆。最近，有关于紫杉醇治疗引发回忆性皮炎的病例报告。
一名转移性肺癌患者接受了纵隔和肋骨的姑息性放疗。由于疾病进展，她随后接受了紫杉醇治疗。
给予紫杉醇后，患者出现急性呼吸困难。随后的胸部X光显示，在与患者放疗野对应的区域出现了实质性混浊。她还在先前接受电子线治疗的部位出现了严重的皮肤反应。
这是少数几例报道的紫杉醇引起回忆性皮炎的病例之一，也提示了回忆性肺炎，据作者所知，这是一种此前未被报道过的现象。鉴于紫杉醇具有放射增敏剂的作用，这种反应并不意外。随着紫杉醇使用频率的增加，应考虑其作为放射增敏剂和引发放射回忆的可能性。
