Department of Psychology, Wesleyan University.
Neuropsychology. 2011 Nov;25(6):784-791. doi: 10.1037/a0025534.
To study the relationship of superior (i.e., ≥ 90th percentile), average (11th-89th percentile) or extremely low (i.e., ≤ 10th percentile) crystallized verbal skills to neurocognitive profiles, symptoms and everyday life function in schizophrenia.
Crystallized verbal skill was derived from Vocabulary subtest scores from the Wechsler Adult Intelligence Scale (WAIS). Out of a sample of 165 stable outpatients with schizophrenia we identified 25 participants with superior crystallized verbal skill, 104 participants with average verbal skill, and 36 participants with extremely low crystallized verbal skill. Each participant was administered measures of attention, working memory, verbal learning and memory, problem-solving and processing speed, as well as symptom and performance-based adaptive life skill assessments.
The magnitude of neuropsychological impairment across the three groups was different, after adjusting for group differences in education and duration of illness. Working memory, and verbal learning and memory skills were different across all three groups, while processing speed differentiated the extremely low verbal skill group from the other two groups and problem-solving differentiated the very low verbal skill group from the superior verbal skill group. There were no group differences in sustained attention. Capacity measures of everyday life skills were different across each of the three groups.
Crystallized verbal skill in schizophrenia is related to the magnitude of impairment in neurocognitive function and performance-based skills in everyday life function. Patterns of neuropsychological impairment were similar across different levels of crystallized verbal skill.
研究优秀（即≥第 90 百分位）、平均（第 11 至第 89 百分位）或极低（即≤第 10 百分位）晶体语言技能与精神分裂症的神经认知特征、症状和日常生活功能的关系。
晶体语言技能由韦氏成人智力量表（WAIS）词汇子测验分数得出。在 165 名稳定的精神分裂症门诊患者中，我们确定了 25 名具有优秀晶体语言技能的参与者、104 名具有平均语言技能的参与者和 36 名具有极低晶体语言技能的参与者。每位参与者都接受了注意力、工作记忆、言语学习和记忆、解决问题和处理速度以及症状和基于表现的适应性生活技能评估。
在调整了教育和疾病持续时间的组间差异后，三组之间的神经心理损伤程度不同。工作记忆和言语学习和记忆技能在所有三组之间存在差异，而处理速度将极低语言技能组与其他两组区分开来，解决问题将极低语言技能组与优秀语言技能组区分开来。三组之间在持续注意力方面没有差异。日常生活技能的能力衡量指标在三组之间存在差异。
精神分裂症中的晶体语言技能与神经认知功能和基于表现的日常生活功能技能的损伤程度有关。在不同的晶体语言技能水平上，神经心理损伤模式相似。
