[头颈部肿瘤患者顺铂所致呕吐的控制。甲氧氯普胺、阿立必利与安慰剂的随机研究]
[Control of the emesis induced by cisplatin in patients with head and neck neoplasms. Randomized study of metoclopramide alizapride and placebo].
作者信息
Denaro A, Rossi M, Garozzo A, Matera M, Neri V
机构信息
Istituto di Clinica Otorinolaringoiatrica, Università degli Studi di Catania.
出版信息
G Ital Oncol. 1990 Jan-Jun;10(1-2):29-34.
A double blind study has been lead on 75 patients affected by head and neck cancer treated with CDDP, to verify the alizapride's antiemetic efficacy versus placebo and metoclopramide. On 76 patients examined, 28 has been treated with CDDP 50 mg/mq + alizapride; 28 with CDDP 50 mg/mq + metoclopramide and finally 19 with CDDP 50 mg/mq + placebo. Both alizapride and metoclopramide administered have resulted effective on the control of the emesis induced with CDDP without side effects.
对75例接受顺铂治疗的头颈癌患者进行了一项双盲研究，以验证阿立必利与安慰剂和甲氧氯普胺相比的止吐疗效。在76例接受检查的患者中，28例接受顺铂50mg/m²+阿立必利治疗；28例接受顺铂50mg/m²+甲氧氯普胺治疗，最后19例接受顺铂50mg/m²+安慰剂治疗。所给予的阿立必利和甲氧氯普胺均对控制顺铂引起的呕吐有效且无副作用。
Zotero 插件