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[对照双盲研究:阿立必利-甲氧氯普胺]

[Comparative double-blind study: alizapride-metoclopramide].

作者信息

Oberling F

出版信息

Ann Gastroenterol Hepatol (Paris). 1984 Jan-Feb;20(1):59-61.

PMID:6529162
Abstract

The anti-emetic action of alizapride was compared to that of metoclopramide in a strict double-blind study of 57 cases files derived from 21 patients treated with anti-mitotic chemotherapy. For each treatment, each patient received two ampoules before and after the chemotherapy. Each ampoule contained either 50 mg of alizapride or 10 mg of metoclopramide. There were 24 good or excellent results and 4 nil results with alizapride and 16 good or excellent results and 13 nil results with metoclopramide. The superiority of alizapride over metoclopramide was therefore established with statistical significance (0.05 greater than p greater than 0.02).

摘要

在一项针对21例接受抗有丝分裂化疗患者的57份病例档案进行的严格双盲研究中,将阿立必利的止吐作用与甲氧氯普胺进行了比较。对于每种治疗方法,每位患者在化疗前后各接受两支安瓿。每支安瓿含有50毫克阿立必利或10毫克甲氧氯普胺。阿立必利组有24例效果良好或极佳,4例无效果;甲氧氯普胺组有16例效果良好或极佳,13例无效果。因此,阿立必利优于甲氧氯普胺具有统计学意义(0.05>p>0.02)。

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