Dinerman J L, Mehta J L
Department of Medicine, University of Florida College of Medicine, Gainesville.
J Am Coll Cardiol. 1990 Jul;16(1):207-22. doi: 10.1016/0735-1097(90)90481-4.
Recent investigations of the complex interactions among vascular endothelium, platelets and leukocytes have relevance to the pathogenesis of atherosclerosis and ischemic heart disease. Perturbations in the hemodynamic equilibrium maintained by these cellular elements may lead to vasospasm, in vivo thrombosis and a reduction in blood flow. Recent advances in the understanding of these interactions in health and disease states are summarized. The effect of pharmacologic agents on these cell-cell interactions are discussed to provide the reader with a general understanding of the relevance of these interactions in cardiovascular disease.
近期对血管内皮、血小板和白细胞之间复杂相互作用的研究与动脉粥样硬化和缺血性心脏病的发病机制相关。这些细胞成分所维持的血流动力学平衡的紊乱可能导致血管痉挛、体内血栓形成以及血流减少。本文总结了在健康和疾病状态下对这些相互作用理解的最新进展。还讨论了药物制剂对这些细胞间相互作用的影响，以使读者对这些相互作用在心血管疾病中的相关性有一个总体认识。
