Hamilton Regional Cancer Centre, Ontario Cancer Foundation, Hamilton, Ont., Canada.
Int J Antimicrob Agents. 1994;3(4):223-43. doi: 10.1016/0924-8579(94)90050-7.
Biological response modifiers (BRMs) are agents which can modify the immune response to cancer or invasion of the organism by infectious agents. An explosive appearance of new BRMs has resulted from the development of recombinant gene technology and the availability of monoclonal antibodies. Colony-stimulating factors first became available for the prevention of neutropenia but may also have a role in the treatment of infections. Interleukin-1 is being tested as a modular of hematopoiesis and may be useful as a helper factor for T- and B-cell function. Immunoglobulins are being used against viral and bacterial infections while interferons can prevent viral upper respiratory infections and suppress or irradicate some viral hepatitides. Other BRMs which show promise include chemical agents and traditional herbal medicines.
生物反应调节剂（BRMs）是能够修饰机体对癌症或传染性病原体侵袭的免疫反应的物质。随着重组基因技术的发展和单克隆抗体的应用，新型 BRMs 如雨后春笋般涌现。集落刺激因子最初被用于预防中性粒细胞减少症，但也可能在治疗感染方面发挥作用。白细胞介素-1 正在作为造血调节剂进行测试，可能作为 T 细胞和 B 细胞功能的辅助因子有用。免疫球蛋白正被用于对抗病毒和细菌感染，而干扰素可以预防病毒性上呼吸道感染，并抑制或清除某些病毒性肝炎。其他具有潜力的 BRMs 包括化学制剂和传统草药。
