膝关节置换术中使用头孢呋辛进行抗生素预防。
Antibiotic prophylaxis with cefuroxime in arthroplasty of the knee.
作者信息
Johnson D P
机构信息
Nuffield Orthopaedic Centre, Oxford, England.
出版信息
J Bone Joint Surg Br. 1987 Nov;69(5):787-9. doi: 10.1302/0301-620X.69B5.3316240.
Abstract
A randomised prospective trial was undertaken of antibiotic prophylaxis given at various intervals before inflation of the tourniquet for arthroplasty of the knee. Cefuroxime assays of bone and subcutaneous fat from samples collected throughout the operation demonstrated that an interval of 10 minutes was necessary to obtain adequate prophylaxis. Improvement in the timing of antibiotic prophylaxis may result in a reduction in the incidence of infection.
摘要
针对膝关节置换术中在止血带充气前不同时间给予抗生素预防进行了一项随机前瞻性试验。对手术全程采集样本中的骨组织和皮下脂肪进行头孢呋辛检测表明，需要10分钟的间隔时间才能获得充分的预防效果。抗生素预防给药时间的改善可能会降低感染发生率。
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